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Please see Important Safety Information and Medication Guide, including BOXED WARNING.


Lazanda (La-ZAN-da) (fentanyl) nasal spray is a prescription medicine used to manage breakthrough pain in adults with cancer (18 years of age and older) who are already routinely taking other opioid pain medicines around-the-clock for cancer pain.


Do not use Lazanda unless you are regularly using another opioid pain medicine around-the-clock for your cancer pain and your body is used to these medicines (this means that you are opioid tolerant). You can ask your healthcare provider if you are opioid tolerant.

Keep Lazanda in a safe place away from children.

Get emergency medical help right away if:

  • a child takes Lazanda. Lazanda can cause an overdose and death in any child who takes it
  • an adult who has not been prescribed Lazanda takes it
  • an adult who is not already taking opioids around-the-clock takes Lazanda

These are medical emergencies that can cause death.

Always keep Lazanda in a safe place away from children and from anyone for whom it has not been prescribed.

Lazanda can cause life-threatening breathing problems that can lead to death:

  • Do not take Lazanda if you are not opioid tolerant. (Opioid tolerant means that you are already taking other opioid (narcotic) pain medicines around-the-clock for your cancer pain and your body is used to these medicines).
  • If you stop taking your around-the-clock opioid pain medicine for your cancer, you must stop taking Lazanda. You may no longer be opioid tolerant. Talk to your healthcare provider about how to treat your pain.
  • Take Lazanda exactly as prescribed by your healthcare provider. You must not take more than 1 dose of Lazanda for each episode of breakthrough cancer pain. You must wait two hours before treating a new episode of breakthrough cancer pain with Lazanda.
  • Do not switch from Lazanda to other medicines that contain fentanyl without talking with your healthcare provider. The amount of fentanyl in a dose of Lazanda is not the same as the amount of fentanyl in other medicines that contain fentanyl. Your healthcare provider will prescribe a starting dose of Lazanda that may be different than other fentanyl-containing medicine you may have been taking.
  • Never give Lazanda to anyone else, even if they have the same symptoms you have. It may harm them or even cause death.

You should not take Lazanda:

Lazanda is available only through a program called the TIRF REMS ACCESS program. Talk to your healthcare provider for more information.

Before taking Lazanda, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may cause serious or life-threatening medical problems when taken with Lazanda. Sometimes, the doses of certain medicines and Lazanda need to be changed if used together.

Possible side effects of Lazanda:

Call your healthcare provider or get emergency medical help right away if you:

These symptoms can be a sign that you have taken too much Lazanda or the dose is too high for you. These symptoms may lead to serious problems or death if not treated right away. If you have any of these symptoms, do not take any more Lazanda until you have talked to your healthcare provider.

The most common side effects of Lazanda seen in clinical studies are:

Constipation (not often enough or hard bowel movements) is a very common side effect of pain medicines (opioids) including Lazanda and is unlikely to go away without treatment. Talk to your healthcare provider about dietary changes and the use of laxatives (medicines to treat constipation) and stool softeners to prevent or treat constipation while taking Lazanda.

These are not all the possible side effects of Lazanda. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

For more information ask your doctor or pharmacist; or visit for the Medication Guide and the complete full Prescribing Information for Lazanda, which includes a Boxed Warning.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit; or call 1-800-FDA-1088). You can also report side effects to Depomed by calling 1-866-435-6775.

Terms and Conditions